Some medical trials follow an adaptive design, which means that the study incorporates the possibility for modification part way through based on interim data findings. What are the benefits of this approach?
Planning adaptive trials helps to keep the scientific integrity of the study while also allowing for far greater flexibility in the field of clinical research. The objectives for adaptive trials include making trials more efficient and informative. This kind of approach is so important in today’s world of clinical research where drop-out rates are high, research periods are long and drawn out and costs are ever increasing. An adaptive trial offers a more flexible approach to try to get to the results quicker and more cost effectively.
Adaptive design trials have been highly effective in the research for rare diseases and rare oncology. Compared to the traditional approach of a medical trial, adaptive design can:
Provide the same information as traditional studies but in a more efficient way
Everyone involved can benefit from this increased efficiency as patients are more likely to get better treatment during the duration of the trial if modifications can be made.
Amendments to treatments allow more patients access to superior treatment regimes and decreases the number of participants possibly being exposed to ineffective or harmful dosage.
The companies behind the sponsoring of the treatment will ultimately have lower development costs for the product and might need to run less trials in the future. For more information on Paid Clinical Trials, visit Trials R Us.
Those completing the research are more likely to find and publish highly relevant clinical results.
In the current climate of tightening financial belts and uncertainty, adaptive design offers a better approach for finding the best use of limited funding. Saving money can come in the form of early termination of an ineffective trial or an obviously highly effective treatment that requires no further trialling. The ability to modify the trial while it’s taking place also allows for the adjustment of the sample patient size which helps avoid a trial failing due to lack of participation.
Adaptive design provides a greater opportunity to achieve the trials objective. It also provides researchers with stronger initial data, the response rate of different doses and the differences between sub-groups of patients. One reason given for this is that an adaptive trial better reflects a real-life clinical setting where these products would be used, rather than a conventional trial setting.
Adaptive design also aids more ethical approaches to trials. The core principles for research ethics include respect for persons, justice and beneficence. These are served by assessing risks and benefits of Paid Clinical Trials, the opportunity for informed consent and the selection of subjects. With certain types of adaptive study, researchers are better able to observe the basic principles of ethics. For example, they are better able to decrease the chances of patients randomly receiving ineffective treatments.